This may lead to symptoms of nausea, vomiting, dizziness, and fatigue. The vestibular system is responsible for balance and coordination, and vestibular disease occurs when this system is overstimulated. Often called "travel sickness," motion sickness happens when the vestibular system located in your inner ear is overstimulated. It is essentially a less potent form of Benadryl in its sedative and anxiety-reducing effects and carries with it a set of low-risk side effects or drug interactions. ![]() Though Dramamine is not FDA-approved for use to treat dogs as it is in humans, you'll find many a vet willing to prescribe the drug. Therefore, it's important to speak with your veterinarian before giving your dog any medication, even something as seemingly innocuous as Dramamine. However, it's important to be aware that drug interactions are always a possibility. These drugs work as central nervous system depressants, which can help to calm an anxious or excited dog. It combines the active ingredient diphenhydramine with 8-chlorotheophylline, which is a mild stimulant similar to caffeine, to counteract the nauseating effects of an overstimulated vestibular system.Īnticholinergic drugs like Dramamine are often used to treat dogs who suffer from motion sickness. If you're planning a road trip with your furry friend, ask your veterinarian if Dramamine is right for them.ĭramamine, also known by its generic name dimenhydrinate, is an antihistamine and anticholinergic drug. In severe cases, your pet may lose its balance and fall over. Symptoms of vestibular disease include nausea, vomiting, and dizziness. This system is responsible for controlling your sense of balance, and can be thrown out of whack when traveling in a vehicle. 1, pp.Dramamine is a medicine used to reduce symptoms of motion sickness by disrupting the vestibular system in your pet's ears. Journal: Journal of Vestibular Research, vol. Keywords: chlorpheniramine, motion sickness, neuropsychological tests, cutaneous administration Chlorpheniramine also has the potential to be administered transdermally. Conclusion:Chlorpheniramine is effective and could be considered for use against motion sickness. Subjects reported significantly more sleepiness and less alertness with high-dose chlorpheniramine, although they could not reliably determine when they had received active drug. Chlorpheniramine did not affect performance on objective cognitive tests. Results:Chlorpheniramine significantly increased the time in the chair compared to placebo at high dose (7.2 minutes to 11.7 minutes) and low dose (7.2 minutes to 10.2 minutes). Cognitive testing included a battery of objective and subjective tests performed before drug ingestion, at peak drug effect and following rotation. ![]() ![]() Eighteen normal, motion sickness susceptible subjects received placebo, low dose (4 mg) or high dose (12 mg) chlorpheniramine 3.5 hours before off-axis vertical rotation. A placebo-controlled, double-blind, dose-ranging trial was performed to establish the most effective dose and the drug's effects on cognition. Methods:We studied chlorpheniramine as a potential motion sickness treat ment. Many motion sickness remedies are also sedating, making them undesirable in many settings. Tel.: +1 6 Fax: +1 6 E-mail: Ībstract: Background:Motion sickness remains a significant problem for travelers and for those involved in naval, aviation and space operations. Buckey, Jr., M.D., Associate Professor of Medicine, Department of Medicine, Dartmouth-Hitchcock Medical Center, One Medical Center Dr. ![]() * | Alvarenga, Donna | Cole, Bernard | Rigas, James R.Īffiliations: Department of Medicine, Dartmouth Medical School, One Medical Center Dr., Lebanon, New Hampshire 03756, USAĬorresponding author: Jay C.
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